New methods for C-C glycosylation Application in the synthesis of Tuberculosis antigens

Tuberculosis (TB) is the only disease ever declared a global emergency by the WHO, it continues to cause great mortality and suffering, especially in poor and less-developed countries. Its association with the HIV/AIDS pandemic forms a lethal combination. The bacillu (Mycobacterium tuberculosis) has a very thick and complex cell wall which makes this pathogen could escape from the host's immune defense and the anti-tuberculosis drugs. In this book, a general method for stereoselective C-C glycosylaiton was developed and this methodology could be applied to synthesize Tuberculosis antigens.