BUKHARI, S: OBESITY

Forty (40) age matched individuals of male and female, young and old were selected as normal and obese on the basis of their body mass index (BMI). A significant increase in concentration of serum glucose, cholesterol, triglyceride, LDL, albumin, ALT, AST, total oxidant status, MDA and Hcy and a significant decrease in concentration of HDL, total proteins, globulins and antioxidant status (AOS) were observed in obese as compared to normal individuals. Sodium, potassium, magnesium and manganese concentration were significantly high and calcium, CU, Zn and Fe concentration did decrease significantly in obese individuals. Serum globulin, total antioxidant status and iron concentration were negative while body mass index, systolic blood pressure, glucose, cholesterol, triglyceride, LDL, albumin, ALT, total oxidants status, MDA, sodium and manganese did show a positive correlation with Hcy in obese individuals. DNA damage was positively correlated with BMI, systolic blood pressure, cholesterol, triglycerides, LDL, albumin, ALT, total oxidant status, MDA, sodium, potassium and magnesium while negative correlation was observed with globulin, AOS and iron contents